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Brand Names: Afloxan
Generic name: Proglumetacin
Painful Joint Disorders: Arthritis, osteoarthritis, rheumatoid arthritis.
Rheumatic Disorders: Chronic progressive polyarthritis, acute articular rheumatism, osteoarthrosis wherever localized, spondylarthritis, acute gout arthritis.
Traumatology: Muscular sprains, strains, bruises; co-adjuvant in distortions and fractures; recovery from orthopedic surgery.
Extraperiarticular and Extraperivascular Disorders: Periarthritis, fibrositis, myositis, tendinitis, bursitis, synovitis, tenosynovitis, stiff neck, neuralgia, neuritis, adnexitis, low back pain (lumbago), sciatica, phlebitis, thrombophlebitis.
Otorhinolaryngology: Otitis, mastoiditis, sinusitis, rhinopharyngitis, tonsillitis.
Capsule: Initial Treatment: 3-4 caps daily in 2 divided doses at meals during ≥2 weeks, according to medical prescription. In severe cases, the dose may be increased up to 6 caps daily in 3 divided doses at meals.
Maintenance Treatment: 2-3 caps daily in 2 divided doses at meals, according to medical prescription.
Tablet: 2 tabs daily in 2 divided doses at meals during ≥2 weeks, according to medical prescription.
Maintenance Treatment: 1 tab daily in 2 divided doses at meals, according to medical prescription.
Should be taken with food (Take at meals.).
Patients already allergic or hypersensitive to the treatment with indoleacetic acid derivatives. As all the prostaglandin inhibitors, it is contraindicated in the last weeks of pregnancy.
Afloxan has a great index of gastro safety. However, its administration to patients with active or recurrent gastroduodenal ulcers should be done under medical control. Patients with renal failure and disorders of the central nervous system should be carefully monitored.
Use in pregnancy & lactation:
Afloxan should be administered to pregnant or breastfeeding women, when necessary, under medical control.
Use in children:
As clinical information on the paediatric use is still not available, reduced doses according to the body weight should be done under medical control.
Clinical trials evidenced the safety of Afloxan; however, transient nausea, constipation, epigastric pain and headache may be recorded.
Mechanism of Action
Anti-inflammatory, analgesic and antipyretic.
Pharmacology: Afloxan has fast onset and a long duration of action. Its basic mechanism of action relies mainly on the inhibition of the biosynthesis of prostaglandins. Proglumetacin has little or if any, influence on the gastric mucosa, therefore it is safe to the stomach. It does not impair the metabolic function of the articular cartilage.