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Brand Name: Avandia
Generic Name: Rosiglitazone maleate
QUALITATIVE AND QUANTITATIVE COMPOSITION
Avandia – (Rosiglitazone maleate) is an oral antidiabetic agent which acts primarily by increasing insulin sensitivity. Avandia is used In the management of type 2 diabetes mellitus (also known as non-insulin dependent diabetes mellitus (NIDDM) or adult -onset diabetes).
Avandia improves glycaemic control while reducing circulating insulin levels. Pharmacological studies in animal models indicate that Rosiglitazone improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluco-neogenesis. Rosiglitazone is not chemically or functionally related to the sulphonylureas, the biguandies, or the alpha-glucosidase inhibitors.
Rosiglitazione is a white to off-white solid with a melting point range from 122° to 123°C. The pKa, values of rosiglitazone are 6.8 and 6.1. It is readily soluble in ethanol and a buffered aqueous solution with pH of 2.3; solubility decreases with increasing pH in the physiological range.
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