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Terbutaline Sulfate

Generic name: Terbutaline Sulfate
Brand names:
Brethine, Bricanyl, or Brethaire

Adrenergic agonist which predominantly stimulates beta2-receptors, thus producing relaxation of bronchial smooth muscle. The effect has a duration of up to 8 hours.

Bronchial asthma. Chronic bronchitis, emphysema and other lung diseases where bronchospasm is a complicating factor. Pre-term labor.

Hypersensitivity to any of the ingredients.

Terbutaline Sulfate/Bricanyl tablets should be used as maintenance therapy. Dosage is individual.


Adults: In general, the recommended dose during the first 1–2 weeks is, one tablet (2.5 mg) three times a day. May be increased to 2 tablets, three times a day.
Children: 0.075 mg/kg body weight, three times a day.
Pre-term labor: The drug must be individually titrated. Initial treatment is an infusion of Bricanyl solution for injection followed by oral maintenance therapy with Terbutaline Sulfate/Bricanyl tablets.

Warnings and Precautions:
Caution in patients with thyrotoxicosis and severe cardiovascular disorder. Additional blood glucose controls are recommended initially in diabetics. The hypokalemic effect of beta2-agonists may be potentiated by concomitant treatments (see Interactions). Particular caution is recommended in acute severe asthma. Serum potassium levels should be monitored in those situations.

Pregnancy and lactation:
As with other drugs administered during pregnancy, the benefits for the mother should be weighed against the risks for the fetus.

Undesirable effects:
Tremor, headache, tonic muscle cramps, and palpitations have been recorded. Tolerance to these effects usually develops within 1–2 weeks. Urticaria and exanthema may occur. Sleep and behavioral disturbances have been observed.

The effect of beta-agonists may be inhibited by beta-receptor blocking agents (especially those which are non-selective). Concomitant treatment with xanthines, steroids, or diuretics may potentiate hypokalemia.

This drug is shipped in blisters.

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